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Phosphodiesterase-4 inhibition as a therapeutic approach to treat capillary leakage in systemic inflammation

In sepsis and systemic inflammation, increased microvascular permeability and consecutive breakdown of microcirculatory flow significantly contribute to organ failure and death. Evidence points to a critical role of cAMP levels in endothelial cells to maintain capillary endothelial barrier propertie...

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Bibliographic Details
Main Authors: Schick, Martin Alexander, Wunder, Christian, Wollborn, Jakob, Roewer, Norbert, Waschke, Jens, Germer, Christoph-Thomas, Schlegel, Nicolas
Format: Artigo
Language:Inglês
Published: Blackwell Science Inc 2012
Subjects:
Cardiovascular
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC3424725/
https://ncbi.nlm.nih.gov/pubmed/22495586
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1113/jphysiol.2012.232116
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