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A hyperactive Mpl-based cell growth switch drives macrophage-associated erythropoiesis through an erythroid-megakaryocytic precursor

Several approaches for controlling hematopoietic stem and progenitor cell expansion, lineage commitment, and maturation have been investigated for improving clinical interventions. We report here that amino acid substitutions in a thrombopoietin receptor (Mpl)--containing cell growth switch (CGS) ex...

Ausführliche Beschreibung

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Bibliographische Detailangaben
Veröffentlicht in:Blood
Hauptverfasser: Belay, Eyayu, Miller, Chris P., Kortum, Amanda N., Torok-Storb, Beverly, Blau, C. Anthony, Emery, David W.
Format: Artigo
Sprache:Inglês
Veröffentlicht: American Society of Hematology 2015
Schlagworte:
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC4319233/
https://ncbi.nlm.nih.gov/pubmed/25343958
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1182/blood-2014-02-555318
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