A hyperactive Mpl-based cell growth switch drives macrophage-associated erythropoiesis through an erythroid-megakaryocytic precursor

Several approaches for controlling hematopoietic stem and progenitor cell expansion, lineage commitment, and maturation have been investigated for improving clinical interventions. We report here that amino acid substitutions in a thrombopoietin receptor (Mpl)--containing cell growth switch (CGS) ex...

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Bibliographic Details
Published in:Blood
Main Authors: Belay, Eyayu, Miller, Chris P., Kortum, Amanda N., Torok-Storb, Beverly, Blau, C. Anthony, Emery, David W.
Format: Artigo
Language:Inglês
Published: American Society of Hematology 2015
Subjects:
Red Cells, Iron, and Erythropoiesis
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC4319233/
https://ncbi.nlm.nih.gov/pubmed/25343958
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1182/blood-2014-02-555318
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