A hyperactive Mpl-based cell growth switch drives macrophage-associated erythropoiesis through an erythroid-megakaryocytic precursor

Several approaches for controlling hematopoietic stem and progenitor cell expansion, lineage commitment, and maturation have been investigated for improving clinical interventions. We report here that amino acid substitutions in a thrombopoietin receptor (Mpl)--containing cell growth switch (CGS) ex...

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Bibliografske podrobnosti
izdano v:Blood
Main Authors: Belay, Eyayu, Miller, Chris P., Kortum, Amanda N., Torok-Storb, Beverly, Blau, C. Anthony, Emery, David W.
Format: Artigo
Jezik:Inglês
Izdano: American Society of Hematology 2015
Teme:
Red Cells, Iron, and Erythropoiesis
Online dostop:https://ncbi.nlm.nih.gov/pmc/articles/PMC4319233/
https://ncbi.nlm.nih.gov/pubmed/25343958
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1182/blood-2014-02-555318
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