A Quantitative Assay Reveals Ligand Specificity of the DNA Scaffold Repair Protein XRCC1 and Efficient Disassembly of Complexes of XRCC1 and the Poly(ADP-ribose) Polymerase 1 by Poly(ADP-ribose) Glycohydrolase

The posttranslational modification of proteins with poly(ADP-ribose) (PAR) regulates protein-protein interactions in DNA repair, gene expression, chromatin structure, and cell fate determination. The PAR polymerase PARP1 binds to damaged chromatin and synthesizes PAR chains to signal DNA damage and...

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Detalles Bibliográficos
Publicado en:J Biol Chem
Main Authors: Kim, In-Kwon, Stegeman, Roderick A., Brosey, Chris A., Ellenberger, Tom
Formato: Artigo
Idioma:Inglês
Publicado: American Society for Biochemistry and Molecular Biology 2015
Assuntos:
Molecular Biophysics
Acceso en liña:https://ncbi.nlm.nih.gov/pmc/articles/PMC4319041/
https://ncbi.nlm.nih.gov/pubmed/25477519
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M114.624718
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