Stanniocalcin-2 Inhibits Mammalian Growth by Proteolytic Inhibition of the Insulin-like Growth Factor Axis

Mammalian stanniocalcin-2 (STC2) is a secreted polypeptide widely expressed in developing and adult tissues. However, although transgenic expression in mice is known to cause severe dwarfism, and targeted deletion of STC2 causes increased postnatal growth, its precise biological role is still unknow...

Disgrifiad llawn

Wedi'i Gadw mewn:
Manylion Llyfryddiaeth
Cyhoeddwyd yn:J Biol Chem
Prif Awduron: Jepsen, Malene R., Kløverpris, Søren, Mikkelsen, Jakob H., Pedersen, Josefine H., Füchtbauer, Ernst-Martin, Laursen, Lisbeth S., Oxvig, Claus
Fformat: Artigo
Iaith:Inglês
Cyhoeddwyd: American Society for Biochemistry and Molecular Biology 2015
Pynciau:
Enzymology
Mynediad Ar-lein:https://ncbi.nlm.nih.gov/pmc/articles/PMC4319012/
https://ncbi.nlm.nih.gov/pubmed/25533459
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M114.611665
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