The ribonuclease activity of SAMHD1 is required for HIV-1 restriction

The HIV-1 restriction factor SAMHD1(1,2) is proposed to inhibit HIV-1 replication by depleting the intracellular dNTP pool(3-5). However, the phosphorylation of SAMHD1 regulates its ability to restrict HIV-1 without decreasing cellular dNTP levels(6-8), which is not consistent with a role for SAMHD1...

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Pubblicato in:Nat Med
Autori principali: Ryoo, Jeongmin, Choi, Jongsu, Oh, Changhoon, Kim, Sungchul, Seo, Minji, Kim, Seokyoung, Seo, Daekwan, Kim, Jongkyu, White, Tommy E., Brandariz-Nunez, Alberto, Diaz-Griffero, Felipe, Yun, Cheol-Heui, Hollenbaugh, Joseph A., Kim, Baek, Baek, Daehyun, Ahn, Kwangseog
Natura: Artigo
Lingua:Inglês
Pubblicazione: 2014
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Article
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC4318684/
https://ncbi.nlm.nih.gov/pubmed/25038827
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/nm.3626
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