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A subset of membrane-altering agents and γ-secretase modulators provoke non-substrate cleavage by rhomboid proteases
Rhomboid proteases are integral membrane enzymes that regulate cell signaling, adhesion, and organelle homeostasis pathways, making substrate specificity a key feature of their function. Interestingly, we found that perturbing the membrane pharmacologically in living cells had little effect on subst...
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| Publicado no: | Cell Rep |
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| Main Authors: | , |
| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
2014
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC4318640/ https://ncbi.nlm.nih.gov/pubmed/25159145 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.celrep.2014.07.039 |
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