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Membrane immersion allows rhomboid proteases to achieve specificity by reading transmembrane segment dynamics

Rhomboid proteases reside within cellular membranes, but the advantage of this unusual environment is unclear. We discovered membrane immersion allows substrates to be identified in a fundamentally-different way, based initially upon exposing ‘masked’ conformational dynamics of transmembrane segment...

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Detalhes bibliográficos
Main Authors: Moin, Syed M, Urban, Sinisa
Formato: Artigo
Idioma:Inglês
Publicado em: eLife Sciences Publications, Ltd 2012
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3494066/
https://ncbi.nlm.nih.gov/pubmed/23150798
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.7554/eLife.00173
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