Helix 8 and the i3 Loop of the Muscarinic M3 Receptor Are Crucial Sites for Its Regulation by the Gβ5-RGS7 Complex

[Image: see text] The muscarinic M3 receptor (M3R) is a Gq-coupled receptor and is known to interact with many intracellular regulatory proteins. One of these molecules is Gβ5-RGS7, the permanently associated heterodimer of G protein β-subunit Gβ5 and RGS7, a regulator of G protein signaling. Gβ5-RG...

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Publicado en:Biochemistry
Autores principales: Karpinsky-Semper, Darla, Tayou, Junior, Levay, Konstantin, Schuchardt, Brett J., Bhat, Vikas, Volmar, Claude-Henry, Farooq, Amjad, Slepak, Vladlen Z.
Formato: Artigo
Lenguaje:Inglês
Publicado: American Chemical Society 2014
Acceso en línea:https://ncbi.nlm.nih.gov/pmc/articles/PMC4318586/
https://ncbi.nlm.nih.gov/pubmed/25551629
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/bi500980d
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