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Differential Effects of the Gβ5-RGS7 Complex on Muscarinic M3 Receptor–Induced Ca(2+) Influx and Release
The G protein β subunit Gβ5 uniquely forms heterodimers with R7 family regulators of G protein signaling (RGS) proteins (RGS6, RGS7, RGS9, and RGS11) instead of Gγ. Although the Gβ5-RGS7 complex attenuates Ca(2+) signaling mediated by the muscarinic M3 receptor (M3R), the route of Ca(2+) entry (i.e....
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| Main Authors: | , , , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
The American Society for Pharmacology and Experimental Therapeutics
2014
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC4170115/ https://ncbi.nlm.nih.gov/pubmed/24586057 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1124/mol.114.091843 |
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