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Differential Effects of the Gβ5-RGS7 Complex on Muscarinic M3 Receptor–Induced Ca(2+) Influx and Release

The G protein β subunit Gβ5 uniquely forms heterodimers with R7 family regulators of G protein signaling (RGS) proteins (RGS6, RGS7, RGS9, and RGS11) instead of Gγ. Although the Gβ5-RGS7 complex attenuates Ca(2+) signaling mediated by the muscarinic M3 receptor (M3R), the route of Ca(2+) entry (i.e....

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Autors principals: Karpinsky-Semper, Darla, Volmar, Claude-Henry, Brothers, Shaun P., Slepak, Vladlen Z.
Format: Artigo
Idioma:Inglês
Publicat: The American Society for Pharmacology and Experimental Therapeutics 2014
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Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC4170115/
https://ncbi.nlm.nih.gov/pubmed/24586057
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1124/mol.114.091843
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