Re-directing apoptosis to aponecrosis induces selective cytotoxicity to pancreatic cancer cells through increased ROS, decline in ATP levels and VDAC

Pancreatic cancer cell lines with mutated ras underwent an alternative form of cell death (aponecrosis) when treated concomitantly with clinically achievable concentrations of arsenic trioxide, ascorbic acid and disulfiram (Antabuse™) (AAA). AAA's major effects are mediated through generation o...

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Publicado en:Mol Cancer Ther
Autores principales: Dinnen, Richard D., Mao, Yuehua, Qiu, Wanglong, Cassai, Nicholas, Slavkovich, Vesna N., Nichols, Gwen, Su, Gloria H., Brandt-Rauf, Paul, Fine, Robert L.
Formato: Artigo
Lenguaje:Inglês
Publicado: 2013
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Article
Acceso en línea:https://ncbi.nlm.nih.gov/pmc/articles/PMC4318573/
https://ncbi.nlm.nih.gov/pubmed/24126434
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1158/1535-7163.MCT-13-0234
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