Re-directing apoptosis to aponecrosis induces selective cytotoxicity to pancreatic cancer cells through increased ROS, decline in ATP levels and VDAC

Pancreatic cancer cell lines with mutated ras underwent an alternative form of cell death (aponecrosis) when treated concomitantly with clinically achievable concentrations of arsenic trioxide, ascorbic acid and disulfiram (Antabuse™) (AAA). AAA's major effects are mediated through generation o...

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Veröffentlicht in:Mol Cancer Ther
Hauptverfasser: Dinnen, Richard D., Mao, Yuehua, Qiu, Wanglong, Cassai, Nicholas, Slavkovich, Vesna N., Nichols, Gwen, Su, Gloria H., Brandt-Rauf, Paul, Fine, Robert L.
Format: Artigo
Sprache:Inglês
Veröffentlicht: 2013
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Article
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC4318573/
https://ncbi.nlm.nih.gov/pubmed/24126434
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1158/1535-7163.MCT-13-0234
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