A Model in which Hsp90 Targets Protein Folding Clefts: rationale for a New Approach to Neuroprotective Treatment of Protein Folding Diseases

Eitemau Tebyg

• The Hsp90 Chaperone Machinery Regulates Signaling by Modulating Ligand Binding Clefts
  gan: Pratt, William B., et al.
  Cyhoeddwyd: (2008)
• Targeting Proteostasis Through the Protein Quality Control Function of the Hsp90/Hsp70-based Chaperone Machinery for Treatment of Adult Onset Neurodegenerative Diseases
  gan: Pratt, William B., et al.
  Cyhoeddwyd: (2014)
• Modulation of Heme/Substrate Binding Cleft of Neuronal Nitric-oxide Synthase (nNOS) Regulates Binding of Hsp90 and Hsp70 Proteins and nNOS Ubiquitination
  gan: Peng, Hwei-Ming, et al.
  Cyhoeddwyd: (2012)
• Role of the Hsp90/Hsp70-Based Chaperone Machinery in Making Triage Decisions When Proteins Undergo Oxidative and Toxic Damage
  gan: Pratt, William B., et al.
  Cyhoeddwyd: (2010)
• Inhibition of Hsp70 by Methylene Blue Affects Signaling Protein Function and Ubiquitination and Modulates Polyglutamine Protein Degradation
  gan: Wang, Adrienne M., et al.
  Cyhoeddwyd: (2010)