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Mosaic mice with teratocarcinoma-derived mutant cells deficient in hypoxanthine phosphoribosyltransferase

Mutagenized stem cells of a cultured mouse teratocarcinoma cell line were selected for resistance to the purine base analog 6-thioguanine. Cells of a resistant clone were completely deficient in activity of the enzyme hypoxanthine phosphoribosyltransferase (HPRT, IMP:pyrophosphate phosphoribosyltran...

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Detalhes bibliográficos
Publicado no:Proc Natl Acad Sci U S A
Main Authors: Dewey, Michael J., Martin, David W., Martin, Gail R., Mintz, Beatrice
Formato: Artigo
Idioma:Inglês
Publicado em: National Academy of Sciences 1977
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Acesso em linha:https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC431809/
https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/271982/
https://ncbi.nlm.nih.govhttps://doi.org/10.1073/pnas.74.12.5564
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