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Mosaic mice with teratocarcinoma-derived mutant cells deficient in hypoxanthine phosphoribosyltransferase

Mutagenized stem cells of a cultured mouse teratocarcinoma cell line were selected for resistance to the purine base analog 6-thioguanine. Cells of a resistant clone were completely deficient in activity of the enzyme hypoxanthine phosphoribosyltransferase (HPRT, IMP:pyrophosphate phosphoribosyltran...

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Autori principali: Dewey, Michael J., Martin, David W., Martin, Gail R., Mintz, Beatrice
Natura: Artigo
Lingua:Inglês
Pubblicazione: 1977
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Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC431809/
https://ncbi.nlm.nih.gov/pubmed/271982
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