Loss of hepatocyte growth factor activator inhibitor type 1 participates in metastatic spreading of human pancreatic cancer cells in a mouse orthotopic transplantation model

Hepatocyte growth factor activator inhibitor type 1 (HAI-1) is a membrane-bound serine protease inhibitor that is expressed on the surface of epithelial and carcinoma cells. On the cell surface, HAI-1 regulates membrane-anchored serine proteases, with matriptase being the most critical target. Matri...

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Veröffentlicht in:Cancer Sci
Hauptverfasser: Ye, Jingjia, Kawaguchi, Makiko, Haruyama, Yukihiro, Kanemaru, Ai, Fukushima, Tsuyoshi, Yamamoto, Koji, Lin, Chen-Yong, Kataoka, Hiroaki
Format: Artigo
Sprache:Inglês
Veröffentlicht: BlackWell Publishing Ltd 2014
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Original Articles
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC4317873/
https://ncbi.nlm.nih.gov/pubmed/24147538
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1111/cas.12306
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