WHI-P154 enhances the chemotherapeutic effect of anticancer agents in ABCG2-overexpressing cells

ATP-binding cassette (ABC) transmembrane proteins evidently decrease the intracellular accumulation of substrate chemotherapeutic drugs by extruding them against a concentration gradient, thereby inducing drug resistance. Here we reported the effect of WHI-P154, an irreversible inhibitor of Janus ki...

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Detalhes bibliográficos
Publicado no:Cancer Sci
Main Authors: Zhang, Hui, Zhang, Yun-Kai, Wang, Yi-Jun, Kathawala, Rishil J, Patel, Atish, Zhu, Hua, Sodani, Kamlesh, Talele, Tanaji T, Ambudkar, Suresh V, Chen, Zhe-Sheng, Fu, Li-Wu
Formato: Artigo
Idioma:Inglês
Publicado em: Blackwell Publishing Ltd 2014
Assuntos:
Original Articles
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4317847/
https://ncbi.nlm.nih.gov/pubmed/24903205
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1111/cas.12462
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