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Dissociation of tumor promoter-stimulated ornithine decarboxylase activity and DNA synthesis in mouse epidermis in vivo and in vitro by fluocinolone acetonide, a tumor-promotion inhibitor.

12-O-Tetradecanoyl phorbol-13-acetate (TPA), a tumor promoter, stimulates DNA synthesis in mouse epidermal cells in vivo and in vitro. This response appears to be mediated through polyamine metabolism because ornithine decarboxylase (L-ornithine carboxy-lyase, EC 4.1.1.17)activity is markedly increa...

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Udgivet i:Proc Natl Acad Sci U S A
Principais autores: Lichti, U, Slaga, T J, Ben, T, Patterson, E, Hennings, H, Yuspa, S H
Format: Artigo
Sprog:Inglês
Udgivet: National Academy of Sciences 1977
Fag:
Research Article
Online adgang:https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC431781/
https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/269443/
https://ncbi.nlm.nih.govhttps://doi.org/10.1073/pnas.74.9.3908
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