Lovastatin selectively inhibits ras activation of the 12-O-tetradecanoylphorbol-13-acetate response element in mammalian cells.

To evaluate ras-mediated signal transduction, an alkaline phosphatase gene (SEAP) was placed under the control of the ras-inducible phorbol ester response element (TRE) in murine fibroblasts (TRE-SEAP cells). The Kirsten ras gene was placed under the control of the glucocorticoid-inducible mouse mam...

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Detalhes bibliográficos
Main Authors: Defeo-Jones, D, McAvoy, E M, Jones, R E, Vuocolo, G A, Haskell, K M, Wegrzyn, R J, Oliff, A
Formato: Artigo
Idioma:Inglês
Publicado em: 1991
Assuntos:
Research Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC359936/
https://ncbi.nlm.nih.gov/pubmed/2005914
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