Lovastatin selectively inhibits ras activation of the 12-O-tetradecanoylphorbol-13-acetate response element in mammalian cells.

To evaluate ras-mediated signal transduction, an alkaline phosphatase gene (SEAP) was placed under the control of the ras-inducible phorbol ester response element (TRE) in murine fibroblasts (TRE-SEAP cells). The Kirsten ras gene was placed under the control of the glucocorticoid-inducible mouse mam...

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Detalhes bibliográficos

Publicado no:	Mol Cell Biol
Principais autores:	Defeo-Jones, D, McAvoy, E M, Jones, R E, Vuocolo, G A, Haskell, K M, Wegrzyn, R J, Oliff, A
Formato:	Artigo
Idioma:	Inglês
Publicado em:	Taylor & Francis 1991
Assuntos:	Research Article
Acesso em linha:	https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC359936/ https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/2005914/ https://ncbi.nlm.nih.govhttps://doi.org/10.1128/mcb.11.4.2307-2310.1991
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