UCHL1 provides diagnostic and antimetastatic strategies due to its deubiquitinating effect on HIF-1α

Hypoxia-inducible factor 1 (HIF-1) plays a role in tumour metastases; however, the genes that activate HIF-1 and subsequently promote metastases have yet to be identified. Here we show that Ubiquitin C-terminal hydrolase-L1 (UCHL1) abrogates the von Hippel–Lindau-mediated ubiquitination of HIF-1α, t...

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Detalhes bibliográficos
Publicado no:Nat Commun
Main Authors: Goto, Yoko, Zeng, Lihua, Yeom, Chan Joo, Zhu, Yuxi, Morinibu, Akiyo, Shinomiya, Kazumi, Kobayashi, Minoru, Hirota, Kiichi, Itasaka, Satoshi, Yoshimura, Michio, Tanimoto, Keiji, Torii, Masae, Sowa, Terumasa, Menju, Toshi, Sonobe, Makoto, Kakeya, Hideaki, Toi, Masakazu, Date, Hiroshi, Hammond, Ester M., Hiraoka, Masahiro, Harada, Hiroshi
Formato: Artigo
Idioma:Inglês
Publicado em: Nature Pub. Group 2015
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4317501/
https://ncbi.nlm.nih.gov/pubmed/25615526
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/ncomms7153
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