UCHL1 provides diagnostic and antimetastatic strategies due to its deubiquitinating effect on HIF-1α

Hypoxia-inducible factor 1 (HIF-1) plays a role in tumour metastases; however, the genes that activate HIF-1 and subsequently promote metastases have yet to be identified. Here we show that Ubiquitin C-terminal hydrolase-L1 (UCHL1) abrogates the von Hippel–Lindau-mediated ubiquitination of HIF-1α, t...

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Pubblicato in:Nat Commun
Autori principali: Goto, Yoko, Zeng, Lihua, Yeom, Chan Joo, Zhu, Yuxi, Morinibu, Akiyo, Shinomiya, Kazumi, Kobayashi, Minoru, Hirota, Kiichi, Itasaka, Satoshi, Yoshimura, Michio, Tanimoto, Keiji, Torii, Masae, Sowa, Terumasa, Menju, Toshi, Sonobe, Makoto, Kakeya, Hideaki, Toi, Masakazu, Date, Hiroshi, Hammond, Ester M., Hiraoka, Masahiro, Harada, Hiroshi
Natura: Artigo
Lingua:Inglês
Pubblicazione: Nature Pub. Group 2015
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Article
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC4317501/
https://ncbi.nlm.nih.gov/pubmed/25615526
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/ncomms7153
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