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PLK1 blockade enhances therapeutic effects of radiation by inducing cell cycle arrest at the mitotic phase
The cytotoxicity of ionizing radiation depends on the cell cycle phase; therefore, its pharmacological manipulation, especially the induction of cell cycle arrest at the radiosensitive mitotic-phase (M-phase), has been attempted for effective radiation therapy. Polo-like kinase 1 (PLK1) is a serine/...
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| Publicado en: | Sci Rep |
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| Autores principales: | , , , , , , |
| Formato: | Artigo |
| Lenguaje: | Inglês |
| Publicado: |
Nature Publishing Group
2015
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| Materias: | |
| Acceso en línea: | https://ncbi.nlm.nih.gov/pmc/articles/PMC4621528/ https://ncbi.nlm.nih.gov/pubmed/26503893 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/srep15666 |
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