Methylation of ribosomal RNA by NSUN5 is a conserved mechanism modulating organismal lifespan

Several pathways modulating longevity and stress resistance converge on translation by targeting ribosomal proteins or initiation factors, but whether this involves modifications of ribosomal RNA is unclear. Here, we show that reduced levels of the conserved RNA methyltransferase NSUN5 increase the...

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Publicado en:Nat Commun
Main Authors: Schosserer, Markus, Minois, Nadege, Angerer, Tina B., Amring, Manuela, Dellago, Hanna, Harreither, Eva, Calle-Perez, Alfonso, Pircher, Andreas, Gerstl, Matthias Peter, Pfeifenberger, Sigrid, Brandl, Clemens, Sonntagbauer, Markus, Kriegner, Albert, Linder, Angela, Weinhäusel, Andreas, Mohr, Thomas, Steiger, Matthias, Mattanovich, Diethard, Rinnerthaler, Mark, Karl, Thomas, Sharma, Sunny, Entian, Karl-Dieter, Kos, Martin, Breitenbach, Michael, Wilson, Iain B.H., Polacek, Norbert, Grillari-Voglauer, Regina, Breitenbach-Koller, Lore, Grillari, Johannes
Formato: Artigo
Idioma:Inglês
Publicado: Nature Publishing Group 2015
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Article
Acceso en liña:https://ncbi.nlm.nih.gov/pmc/articles/PMC4317494/
https://ncbi.nlm.nih.gov/pubmed/25635753
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/ncomms7158
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