Methylation of ribosomal RNA by NSUN5 is a conserved mechanism modulating organismal lifespan

Several pathways modulating longevity and stress resistance converge on translation by targeting ribosomal proteins or initiation factors, but whether this involves modifications of ribosomal RNA is unclear. Here, we show that reduced levels of the conserved RNA methyltransferase NSUN5 increase the...

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Veröffentlicht in:Nat Commun
Hauptverfasser: Schosserer, Markus, Minois, Nadege, Angerer, Tina B., Amring, Manuela, Dellago, Hanna, Harreither, Eva, Calle-Perez, Alfonso, Pircher, Andreas, Gerstl, Matthias Peter, Pfeifenberger, Sigrid, Brandl, Clemens, Sonntagbauer, Markus, Kriegner, Albert, Linder, Angela, Weinhäusel, Andreas, Mohr, Thomas, Steiger, Matthias, Mattanovich, Diethard, Rinnerthaler, Mark, Karl, Thomas, Sharma, Sunny, Entian, Karl-Dieter, Kos, Martin, Breitenbach, Michael, Wilson, Iain B.H., Polacek, Norbert, Grillari-Voglauer, Regina, Breitenbach-Koller, Lore, Grillari, Johannes
Format: Artigo
Sprache:Inglês
Veröffentlicht: Nature Publishing Group 2015
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Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC4317494/
https://ncbi.nlm.nih.gov/pubmed/25635753
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/ncomms7158
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