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PINK1 Kinase Catalytic Activity Is Regulated by Phosphorylation on Serines 228 and 402

Mutations in the PINK1 gene cause early-onset recessive Parkinson disease. PINK1 is a mitochondrially targeted kinase that regulates multiple aspects of mitochondrial biology, from oxidative phosphorylation to mitochondrial clearance. PINK1 itself is also phosphorylated, and this might be linked to...

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Dades bibliogràfiques
Publicat a:J Biol Chem
Autors principals: Aerts, Liesbeth, Craessaerts, Katleen, De Strooper, Bart, Morais, Vanessa A.
Format: Artigo
Idioma:Inglês
Publicat: American Society for Biochemistry and Molecular Biology 2015
Matèries:
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC4317039/
https://ncbi.nlm.nih.gov/pubmed/25527497
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M114.620906
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