Cardiolipin promotes electron transport between ubiquinone and complex I to rescue PINK1 deficiency

PINK1 is mutated in Parkinson’s disease (PD), and mutations cause mitochondrial defects that include inefficient electron transport between complex I and ubiquinone. Neurodegeneration is also connected to changes in lipid homeostasis, but how these are related to PINK1-induced mitochondrial dysfunct...

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Publicat a:J Cell Biol
Autors principals: Vos, Melissa, Geens, Ann, Böhm, Claudia, Deaulmerie, Liesbeth, Swerts, Jef, Rossi, Matteo, Craessaerts, Katleen, Leites, Elvira P., Seibler, Philip, Rakovic, Aleksandar, Lohnau, Thora, De Strooper, Bart, Fendt, Sarah-Maria, Morais, Vanessa A., Klein, Christine, Verstreken, Patrik
Format: Artigo
Idioma:Inglês
Publicat: The Rockefeller University Press 2017
Matèries:
Research Articles
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC5346965/
https://ncbi.nlm.nih.gov/pubmed/28137779
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1083/jcb.201511044
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