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Amitriptyline Improves Motor Function via Enhanced Neurotrophin Signaling and Mitochondrial Functions in the Murine N171-82Q Huntington Disease Model

Huntington disease (HD) is a neurodegenerative disorder characterized by progressive motor impairment and cognitive alterations. Hereditary HD is primarily caused by the expansion of a CAG trinucleotide repeat in the huntingtin (Htt) gene, which results in the production of mutant huntingtin protein...

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Vydáno v:J Biol Chem
Hlavní autoři: Cong, Wei-Na, Chadwick, Wayne, Wang, Rui, Daimon, Caitlin M., Cai, Huan, Amma, Jennifer, Wood, William H., Becker, Kevin G., Martin, Bronwen, Maudsley, Stuart
Médium: Artigo
Jazyk:Inglês
Vydáno: American Society for Biochemistry and Molecular Biology 2015
Témata:
Neurobiology
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC4317004/
https://ncbi.nlm.nih.gov/pubmed/25505248
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M114.588608
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