Combinatorially selected guanosine-quartet structure is a potent inhibitor of human immunodeficiency virus envelope-mediated cell fusion.

The phosphorothioate oligonucleotide T2G4T2 was identified as an inhibitor of HIV infection in vitro by combinatorial screening of a library of phosphorothioate oligonucleotides that contained all possible octanucleotide sequences. The oligonucleotide forms a parallel-stranded tetrameric guanosine-q...

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Pubblicato in:	Proc Natl Acad Sci U S A
Autori principali:	Wyatt, J R, Vickers, T A, Roberson, J L, Buckheit, R W, Klimkait, T, DeBaets, E, Davis, P W, Rayner, B, Imbach, J L, Ecker, D J
Natura:	Artigo
Lingua:	Inglês
Pubblicazione:	National Academy of Sciences 1994
Soggetti:	Research Article
Accesso online:	https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC43157/ https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/7906414/ https://ncbi.nlm.nih.govhttps://doi.org/10.1073/pnas.91.4.1356
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