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Mechanism of adenylate cyclase activation by cholera toxin: Inhibition of GTP hydrolysis at the regulatory site

Treatment of turkey erthrocyte membranes with cholera toxin caused an enhancement of the basal and catecholamine-stimulated adenylate cyclase [ATP pyrophosphate-lyase (cyclizing), EC 4.6.1.1] activities. Both of these activities required the presence of GTP. The toxin effect on the adenylate cyclase...

Whakaahuatanga katoa

I tiakina i:
Ngā taipitopito rārangi puna kōrero
I whakaputaina i:Proc Natl Acad Sci U S A
Ngā kaituhi matua: Cassel, Dan, Selinger, Zvi
Hōputu: Artigo
Reo:Inglês
I whakaputaina: National Academy of Sciences 1977
Ngā marau:
Urunga tuihono:https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC431542/
https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/198781/
https://ncbi.nlm.nih.govhttps://doi.org/10.1073/pnas.74.8.3307
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