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Mechanism of adenylate cyclase activation by cholera toxin: Inhibition of GTP hydrolysis at the regulatory site

Treatment of turkey erthrocyte membranes with cholera toxin caused an enhancement of the basal and catecholamine-stimulated adenylate cyclase [ATP pyrophosphate-lyase (cyclizing), EC 4.6.1.1] activities. Both of these activities required the presence of GTP. The toxin effect on the adenylate cyclase...

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Autors principals: Cassel, Dan, Selinger, Zvi
Format: Artigo
Idioma:Inglês
Publicat: 1977
Matèries:
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC431542/
https://ncbi.nlm.nih.gov/pubmed/198781
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