Evolutionary Diagnosis of non-synonymous variants involved in differential drug response

BACKGROUND: Many pharmaceutical drugs are known to be ineffective or have negative side effects in a substantial proportion of patients. Genomic advances are revealing that some non-synonymous single nucleotide variants (nsSNVs) may cause differences in drug efficacy and side effects. Therefore, it...

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Bibliographic Details
Published in:BMC Med Genomics
Main Authors: Gerek, Nevin Z, Liu, Li, Gerold, Kristyn, Biparva, Pegah, Thomas, Eric D, Kumar, Sudhir
Format: Artigo
Language:Inglês
Published: BioMed Central 2015
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Research
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC4315320/
https://ncbi.nlm.nih.gov/pubmed/25952014
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/1755-8794-8-S1-S6
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