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The non-random clustering of non-synonymous substitutions and its relationship to evolutionary rate
BACKGROUND: Protein sequences are subject to a mosaic of constraint. Changes to functional domains and buried residues, for example, are more apt to disrupt protein structure and function than are changes to residues participating in loops or exposed to solvent. Regions of constraint on the tertiary...
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| Main Authors: | , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
BioMed Central
2011
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3176261/ https://ncbi.nlm.nih.gov/pubmed/21846337 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/1471-2164-12-415 |
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