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The non-random clustering of non-synonymous substitutions and its relationship to evolutionary rate
BACKGROUND: Protein sequences are subject to a mosaic of constraint. Changes to functional domains and buried residues, for example, are more apt to disrupt protein structure and function than are changes to residues participating in loops or exposed to solvent. Regions of constraint on the tertiary...
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| Autors principals: | , |
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| Format: | Artigo |
| Idioma: | Inglês |
| Publicat: |
BioMed Central
2011
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| Matèries: | |
| Accés en línia: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3176261/ https://ncbi.nlm.nih.gov/pubmed/21846337 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/1471-2164-12-415 |
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