Age-at-Onset in Late Onset Alzheimer Disease is Modified by Multiple Genetic Loci

IMPORTANCE: As APOE locus variants contribute to both risk of late-onset Alzheimer disease and differences in age-at-onset, it is important to know if other established late-onset Alzheimer disease risk loci also affect age-at-onset in cases. OBJECTIVES: To investigate the effects of known Alzheimer...

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Publicado no:JAMA Neurol
Main Authors: Naj, Adam C., Jun, Gyungah, Reitz, Christiane, Kunkle, Brian W., Perry, William, Park, YoSon, Beecham, Gary W., Rajbhandary, Ruchita A., Hamilton-Nelson, Kara L., Wang, Li-San, Kauwe, John S.K., Huentelman, Matthew J., Myers, Amanda J., Bird, Thomas D., Boeve, Bradley F., Baldwin, Clinton T., Jarvik, Gail P., Crane, Paul K., Rogaeva, Ekaterina, Barmada, Michael M., Demirci, F. Yesim, Cruchaga, Carlos, Kramer, Patricia, Ertekin-Taner, Nilufer, Hardy, John, Graff-Radford, Neill R., Green, Robert C., Larson, Eric B., St George-Hyslop, Peter, Buxbaum, Joseph D., Evans, Denis, Schneider, Julie A., Lunetta, Kathryn L., Kamboh, M. Ilyas, Saykin, Andrew J., Reiman, Eric M., De Jager, Philip L., Bennett, David A., Morris, John C., Montine, Thomas J., Goate, Alison M., Blacker, Deborah, Tsuang, Debby W., Hakonarson, Hakon, Kukull, Walter A., Foroud, Tatiana M., Martin, Eden R., Haines, Jonathan L., Mayeux, Richard, Farrer, Lindsay A., Schellenberg, Gerard D., Pericak-Vance, Margaret A.
Formato: Artigo
Idioma:Inglês
Publicado em: 2014
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4314944/
https://ncbi.nlm.nih.gov/pubmed/25199842
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1001/jamaneurol.2014.1491
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