Age-at-Onset in Late Onset Alzheimer Disease is Modified by Multiple Genetic Loci

IMPORTANCE: As APOE locus variants contribute to both risk of late-onset Alzheimer disease and differences in age-at-onset, it is important to know if other established late-onset Alzheimer disease risk loci also affect age-at-onset in cases. OBJECTIVES: To investigate the effects of known Alzheimer...

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Publicat a:JAMA Neurol
Autors principals: Naj, Adam C., Jun, Gyungah, Reitz, Christiane, Kunkle, Brian W., Perry, William, Park, YoSon, Beecham, Gary W., Rajbhandary, Ruchita A., Hamilton-Nelson, Kara L., Wang, Li-San, Kauwe, John S.K., Huentelman, Matthew J., Myers, Amanda J., Bird, Thomas D., Boeve, Bradley F., Baldwin, Clinton T., Jarvik, Gail P., Crane, Paul K., Rogaeva, Ekaterina, Barmada, Michael M., Demirci, F. Yesim, Cruchaga, Carlos, Kramer, Patricia, Ertekin-Taner, Nilufer, Hardy, John, Graff-Radford, Neill R., Green, Robert C., Larson, Eric B., St George-Hyslop, Peter, Buxbaum, Joseph D., Evans, Denis, Schneider, Julie A., Lunetta, Kathryn L., Kamboh, M. Ilyas, Saykin, Andrew J., Reiman, Eric M., De Jager, Philip L., Bennett, David A., Morris, John C., Montine, Thomas J., Goate, Alison M., Blacker, Deborah, Tsuang, Debby W., Hakonarson, Hakon, Kukull, Walter A., Foroud, Tatiana M., Martin, Eden R., Haines, Jonathan L., Mayeux, Richard, Farrer, Lindsay A., Schellenberg, Gerard D., Pericak-Vance, Margaret A.
Format: Artigo
Idioma:Inglês
Publicat: 2014
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Article
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC4314944/
https://ncbi.nlm.nih.gov/pubmed/25199842
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1001/jamaneurol.2014.1491
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