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HIF-1α restricts NF-κB-dependent gene expression to control innate immunity signals

Hypoxia and inflammation are intimately linked. It is known that nuclear factor κB (NF-κB) regulates the hypoxia-inducible factor (HIF) system, but little is known about how HIF regulates NF-κB. Here, we show that HIF-1α represses NF-κB-dependent gene expression. HIF-1α depletion results in increase...

Disgrifiad llawn

Wedi'i Gadw mewn:
Manylion Llyfryddiaeth
Cyhoeddwyd yn:Dis Model Mech
Prif Awduron: Bandarra, Daniel, Biddlestone, John, Mudie, Sharon, Müller, H.-Arno J., Rocha, Sonia
Fformat: Artigo
Iaith:Inglês
Cyhoeddwyd: The Company of Biologists Limited 2015
Pynciau:
Mynediad Ar-lein:https://ncbi.nlm.nih.gov/pmc/articles/PMC4314782/
https://ncbi.nlm.nih.gov/pubmed/25510503
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1242/dmm.017285
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