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HIF-1α restricts NF-κB-dependent gene expression to control innate immunity signals
Hypoxia and inflammation are intimately linked. It is known that nuclear factor κB (NF-κB) regulates the hypoxia-inducible factor (HIF) system, but little is known about how HIF regulates NF-κB. Here, we show that HIF-1α represses NF-κB-dependent gene expression. HIF-1α depletion results in increase...
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| Publicado no: | Dis Model Mech |
|---|---|
| Main Authors: | , , , , |
| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
The Company of Biologists Limited
2015
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC4314782/ https://ncbi.nlm.nih.gov/pubmed/25510503 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1242/dmm.017285 |
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