Endogenous CCL2 neutralization restricts HIV-1 replication in primary human macrophages by inhibiting viral DNA accumulation

BACKGROUND: Macrophages are key targets of HIV-1 infection. We have previously described that the expression of CC chemokine ligand 2 (CCL2) increases during monocyte differentiation to macrophages and it is further up-modulated by HIV-1 exposure. Moreover, CCL2 acts as an autocrine factor that prom...

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Vydáno v:Retrovirology
Hlavní autoři: Sabbatucci, Michela, Covino, Daniela Angela, Purificato, Cristina, Mallano, Alessandra, Federico, Maurizio, Lu, Jing, Rinaldi, Arturo Ottavio, Pellegrini, Matteo, Bona, Roberta, Michelini, Zuleika, Cara, Andrea, Vella, Stefano, Gessani, Sandra, Andreotti, Mauro, Fantuzzi, Laura
Médium: Artigo
Jazyk:Inglês
Vydáno: BioMed Central 2015
Témata:
Research
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC4314729/
https://ncbi.nlm.nih.gov/pubmed/25608886
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/s12977-014-0132-6
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