Transcriptome Profiling of Human Monocyte-Derived Macrophages Upon CCL2 Neutralization Reveals an Association Between Activation of Innate Immune Pathways and Restriction of HIV-1 Gene Expression

Macrophages are key targets of human immunodeficiency virus type 1 (HIV-1) infection and main producers of the proinflammatory chemokine CC chemokine ligand 2 (CCL2), whose expression is induced by HIV-1 both in vitro and in vivo. We previously found that CCL2 neutralization in monocyte-derived macr...

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Detalhes bibliográficos
Publicado no:Front Immunol
Main Authors: Covino, Daniela Angela, Kaczor-Urbanowicz, Karolina Elżbieta, Lu, Jing, Chiantore, Maria Vincenza, Fiorucci, Gianna, Vescio, Maria Fenicia, Catapano, Laura, Purificato, Cristina, Galluzzo, Clementina Maria, Amici, Roberta, Andreotti, Mauro, Gauzzi, Maria Cristina, Pellegrini, Matteo, Fantuzzi, Laura
Formato: Artigo
Idioma:Inglês
Publicado em: Frontiers Media S.A. 2020
Assuntos:
Immunology
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC7531389/
https://ncbi.nlm.nih.gov/pubmed/33072075
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3389/fimmu.2020.02129
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