Transcriptome Profiling of Human Monocyte-Derived Macrophages Upon CCL2 Neutralization Reveals an Association Between Activation of Innate Immune Pathways and Restriction of HIV-1 Gene Expression

Macrophages are key targets of human immunodeficiency virus type 1 (HIV-1) infection and main producers of the proinflammatory chemokine CC chemokine ligand 2 (CCL2), whose expression is induced by HIV-1 both in vitro and in vivo. We previously found that CCL2 neutralization in monocyte-derived macr...

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Publicat a:Front Immunol
Autors principals: Covino, Daniela Angela, Kaczor-Urbanowicz, Karolina Elżbieta, Lu, Jing, Chiantore, Maria Vincenza, Fiorucci, Gianna, Vescio, Maria Fenicia, Catapano, Laura, Purificato, Cristina, Galluzzo, Clementina Maria, Amici, Roberta, Andreotti, Mauro, Gauzzi, Maria Cristina, Pellegrini, Matteo, Fantuzzi, Laura
Format: Artigo
Idioma:Inglês
Publicat: Frontiers Media S.A. 2020
Matèries:
Immunology
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC7531389/
https://ncbi.nlm.nih.gov/pubmed/33072075
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3389/fimmu.2020.02129
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