Endogenous CCL2 neutralization restricts HIV-1 replication in primary human macrophages by inhibiting viral DNA accumulation

BACKGROUND: Macrophages are key targets of HIV-1 infection. We have previously described that the expression of CC chemokine ligand 2 (CCL2) increases during monocyte differentiation to macrophages and it is further up-modulated by HIV-1 exposure. Moreover, CCL2 acts as an autocrine factor that prom...

Full description

Saved in:
Bibliographic Details
Published in:Retrovirology
Main Authors: Sabbatucci, Michela, Covino, Daniela Angela, Purificato, Cristina, Mallano, Alessandra, Federico, Maurizio, Lu, Jing, Rinaldi, Arturo Ottavio, Pellegrini, Matteo, Bona, Roberta, Michelini, Zuleika, Cara, Andrea, Vella, Stefano, Gessani, Sandra, Andreotti, Mauro, Fantuzzi, Laura
Format: Artigo
Language:Inglês
Published: BioMed Central 2015
Subjects:
Research
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC4314729/
https://ncbi.nlm.nih.gov/pubmed/25608886
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/s12977-014-0132-6
Tags: Add Tag
No Tags, Be the first to tag this record!

Similar Items