Identification and X-ray Co-crystal Structure of a Small-Molecule Activator of LFA-1-ICAM-1 Binding**

Stabilization of protein–protein interactions by small molecules is a concept with few examples reported to date. Herein we describe the identification and X-ray co-crystal structure determination of IBE-667, an ICAM-1 binding enhancer for LFA-1. IBE-667 was designed based on the SAR information obt...

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Publicado en:Angew Chem Int Ed Engl
Autores principales: Hintersteiner, Martin, Kallen, Jörg, Schmied, Mario, Graf, Christine, Jung, Thomas, Mudd, Gemma, Shave, Steven, Gstach, Hubert, Auer, Manfred
Formato: Artigo
Lenguaje:Inglês
Publicado: WILEY-VCH Verlag 2014
Materias:
Communication
Acceso en línea:https://ncbi.nlm.nih.gov/pmc/articles/PMC4314669/
https://ncbi.nlm.nih.gov/pubmed/24692345
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1002/anie.201310240
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