Biocompatible Infinite Coordination Polymer Nanoparticle –Nucleic Acid Conjugates For Antisense Gene Regulation

Herein, we report the synthesis of DNA-functionalized infinite coordination polymer (ICP) nanoparticles as biocompatible gene regulation agents. ICP nanoparticles were synthesized from ferric nitrate and a ditopic 3-hydroxy-4-pyridinone (HOPO) ligand bearing a pendant azide. Addition of Fe(III) to a...

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Detalhes bibliográficos
Publicado no:Angew Chem Int Ed Engl
Main Authors: Calabrese, Colin M., Merkel, Timothy J., Briley, William E., Randeria, Pratik S., Narayan, Suguna P., Rouge, Jessica L., Walker, David A., Scott, Alexander W., Mirkin, Chad A.
Formato: Artigo
Idioma:Inglês
Publicado em: 2014
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4314394/
https://ncbi.nlm.nih.gov/pubmed/25393766
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1002/anie.201407946
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