Altered ubiquitin causes perturbed calcium homeostasis, hyperactivation of calpain, dysregulated differentiation, and cataract

Although the ocular lens shares many features with other tissues, it is unique in that it retains its cells throughout life, making it ideal for studies of differentiation/development. Precipitation of proteins results in lens opacification, or cataract, the major blinding disease. Lysines on ubiqui...

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Detalhes bibliográficos
Publicado no:Proc Natl Acad Sci U S A
Main Authors: Liu, Ke, Lyu, Lei, Chin, David, Gao, Junyuan, Sun, Xiurong, Shang, Fu, Caceres, Andrea, Chang, Min-Lee, Rowan, Sheldon, Peng, Junmin, Mathias, Richard, Kasahara, Hideko, Jiang, Shuhong, Taylor, Allen
Formato: Artigo
Idioma:Inglês
Publicado em: National Academy of Sciences 2015
Assuntos:
Biological Sciences
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4313858/
https://ncbi.nlm.nih.gov/pubmed/25583491
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1404059112
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