Giant ankyrin-G: A critical innovation in vertebrate evolution of fast and integrated neuronal signaling

Axon initial segments (AISs) and nodes of Ranvier are sites of clustering of voltage-gated sodium channels (VGSCs) in nervous systems of jawed vertebrates that facilitate fast long-distance electrical signaling. We demonstrate that proximal axonal polarity as well as assembly of the AIS and normal m...

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Udgivet i:Proc Natl Acad Sci U S A
Main Authors: Jenkins, Paul M., Kim, Namsoo, Jones, Steven L., Tseng, Wei Chou, Svitkina, Tatyana M., Yin, Henry H., Bennett, Vann
Format: Artigo
Sprog:Inglês
Udgivet: National Academy of Sciences 2015
Fag:
Biological Sciences
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC4313853/
https://ncbi.nlm.nih.gov/pubmed/25552556
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1416544112
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