ANK2 autism mutation targeting giant ankyrin-B promotes axon branching and ectopic connectivity

Giant ankyrin-B (ankB) is a neurospecific alternatively spliced variant of ANK2, a high-confidence autism spectrum disorder (ASD) gene. We report that a mouse model for human ASD mutation of giant ankB exhibits increased axonal branching in cultured neurons with ectopic CNS axon connectivity, as wel...

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Vydáno v:Proc Natl Acad Sci U S A
Hlavní autoři: Yang, Rui, Walder-Christensen, Kathryn K., Kim, Namsoo, Wu, Danwei, Lorenzo, Damaris N., Badea, Alexandra, Jiang, Yong-Hui, Yin, Henry H., Wetsel, William C., Bennett, Vann
Médium: Artigo
Jazyk:Inglês
Vydáno: National Academy of Sciences 2019
Témata:
PNAS Plus
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC6660793/
https://ncbi.nlm.nih.gov/pubmed/31285321
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1904348116
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