Use of Copper and Insulin-Resistance to Accelerate Cognitive Deficits and Synaptic Protein Loss in a Rat Aβ-Infusion Alzheimer’s Disease Model

The rat amyloid-β (Aβ) intracerebroventricular infusion can model aspects of Alzheimer’s disease (AD) and has predicted efficacy of therapies such as ibuprofen and curcumin in transgenic mouse models. High density lipoprotein (HDL), a normal plasma carrier of Aβ, is used to attenuate Aβ aggregation...

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Detalhes bibliográficos
Publicado no:J Alzheimers Dis
Main Authors: Begum, Aynun N., Yang, Fusheng, Teng, Edmond, Hu, Shuxin, Jones, Mychica R., Rosario, Emily R., Beech, Walter, Hudspeth, Beverly, Ubeda, Oliver J., Cole, Greg M., Frautschy, Sally A.
Formato: Artigo
Idioma:Inglês
Publicado em: 2008
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4313743/
https://ncbi.nlm.nih.gov/pubmed/19096161
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