β-Amyloid Oligomers Induce Phosphorylation of Tau and Inactivation of Insulin Receptor Substrate via c-Jun N-Terminal Kinase Signaling: Suppression by Omega-3 Fatty Acids and Curcumin

Both insulin resistance (type II diabetes) and β-amyloid (Aβ) oligomers are implicated in Alzheimer's disease (AD). Here, we investigate the role of Aβ oligomer-induced c-Jun N-terminal kinase (JNK) activation leading to phosphorylation and degradation of the adaptor protein insulin receptor su...

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Main Authors: Ma, Qiu-Lan, Yang, Fusheng, Rosario, Emily R., Ubeda, Oliver J., Beech, Walter, Gant, Dana J., Chen, Ping Ping, Hudspeth, Beverly, Chen, Cory, Zhao, Yongle, Vinters, Harry V., Frautschy, Sally A., Cole, Greg M.
Formato: Artigo
Idioma:Inglês
Publicado em: Society for Neuroscience 2009
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Articles
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3849615/
https://ncbi.nlm.nih.gov/pubmed/19605645
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1523/JNEUROSCI.1071-09.2009
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