Dysfunctional HIV-specific CD8(+) T cell proliferation is associated with increased caspase-8 activity and mediated by necroptosis

Decreased human immunodeficiency virus (HIV)-specific CD8(+) T cell proliferation is a hallmark of chronic infection, but the mechanisms of decline are unclear. We analyzed gene expression profiles from antigen-stimulated HIV-specific CD8(+) T cells from patients with controlled and uncontrolled inf...

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Detalhes bibliográficos
Publicado no:Immunity
Main Authors: Gaiha, Gaurav D., McKim, Kevin J., Woods, Matthew, Pertel, Thomas, Rohrbach, Janine, Barteneva, Natasha, Chin, Christopher R, Liu, Dongfang, Soghoian, Damien Z, Cesa, Kevin, Wilton, Shannon, Waring, Michael T., Chicoine, Adam, Doering, Travis, Wherry, E. John, Kaufmann, Daniel E., Lichterfeld, Mathias, Brass, Abraham L., Walker, Bruce D.
Formato: Artigo
Idioma:Inglês
Publicado em: 2014
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4312487/
https://ncbi.nlm.nih.gov/pubmed/25526311
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.immuni.2014.12.011
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