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Routes of Administration and Dose Optimization of Soluble Antigen Arrays in Mice with Experimental Autoimmune Encephalomyelitis

Soluble Antigen Arrays (SAgAs) were developed for treating mice with experimental autoimmune encephalomyelitis (EAE), a mouse model of multiple sclerosis. SAgAs are composed of hyaluronan with grafted EAE antigen and LABL peptide (a ligand of ICAM-1). SAgA dose was tested by varying injection volume...

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Detalhes bibliográficos
Publicado no:J Pharm Sci
Main Authors: Thati, Shara, Kuehl, Christopher, Hartwell, Brittany, Sestak, Joshua, Siahaan, Teruna, Forrest, Laird, Berkland, Cory
Formato: Artigo
Idioma:Inglês
Publicado em: 2014
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4312227/
https://ncbi.nlm.nih.gov/pubmed/25447242
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1002/jps.24272
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