DO NOT DROP: MECHANICAL SHOCK IN VIALS CAUSES CAVITATION, PROTEIN AGGREGATION AND PARTICLE FORMATION

Industry experience suggests that g-forces sustained when vials containing protein formulations are accidentally dropped can cause aggregation and particle formation. To study this phenomenon, a shock tower was used to apply controlled g-forces to glass vials containing formulations of two monoclona...

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發表在:J Pharm Sci
Main Authors: Randolph, Theodore W., Schiltz, Elise, Sederstrom, Donn, Steinmann, Daniel, Mozziconacci, Olivier, Schöneich, Christian, Freund, Erwin, Ricci, Margaret S., Carpenter, John F., Lengsfeld, Corrine S.
格式: Artigo
語言:Inglês
出版: 2014
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Article
在線閱讀:https://ncbi.nlm.nih.gov/pmc/articles/PMC4312221/
https://ncbi.nlm.nih.gov/pubmed/25418950
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1002/jps.24259
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