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Protein Kinase D inhibitors uncouple phosphorylation from activity by promoting agonist-dependent activation loop phosphorylation
Protein kinase D (PKD) is acutely activated by two tightly coupled events: binding to the second messenger diacylglycerol (DAG) followed by novel protein kinase C (nPKC) phosphorylation at the activation loop and autophosphorylation at the C-terminus. Thus, phosphorylation serves as a widely accepte...
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| Publicado no: | Chem Biol |
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| Main Authors: | , |
| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
2014
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC4311772/ https://ncbi.nlm.nih.gov/pubmed/25556943 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.chembiol.2014.11.014 |
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